Technische Universität MünchenDec 8

Researchers show how a defect in the #enzyme #GPX4 can trigger #ferroptosis and lead to neuronal loss in certain forms of #dementia. The work provides new insights into cell protection mechanisms: http://go.tum.de/142494

📷T.Orschmann & S. Lorenz

Defective enzyme causes nerve cells to die

Researchers have discovered a protective mechanism in nerve cells that offers new targets for future therapies—especially for dementia.

Brent StockwellNov 23, 2022
Here are thoughts on our new paper published today in @CellChemBiol on targeting #GPX4 to induce #ferroptosis -- link to free download available there. Congrats to the team & Enjoy! @columbia @Columbia_Bio #cancer #biochemistry https://brentstockwell.medium.com/a-new-way-to-target-gpx4-in-aggressive-cancers-28c4881b79ff
A new way to target the ferroptosis regulator GPX4 - Professor Brent R. Stockwell - Medium

Today my lab published a paper in Cell Chemical Biology describing a new way of targeting the central regulator of ferroptosis — the lipid repair enzyme glutathione peroxidase 4 (GPX4). In short, we…

Medium