Bệnh tay chân miệng ở trẻ em đang có dấu hiệu gia tăng do chủng vi rút EV71 (Enterovirus 71), đặc biệt nguy hiểm với trẻ sinh sau năm 2023. Từ tháng 11, số ca nặng đã tăng nhanh do tác nhân này. Bác sĩ khuyến cáo phụ huynh cần theo dõi sát các triệu chứng như sốt cao, bỏ ăn, quấy khóc, run chi... để phát hiện sớm và đưa trẻ đi khám kịp thời. Vệ sinh cá nhân, rửa tay thường xuyên và tiêu độc môi trường là biện pháp phòng ngừa hiệu quả.

#TayChanMieng #EV71 #TreEm #SucKhoe #BenhHoc #Health #ChildH

⚡️ Bệnh tay chân miệng tăng cao tại TP.HCM, nguyên nhân chính EV71. Nhiều trẻ nhập viện phải thở máy, lọc máu do biến chứng nặng. Phụ huynh cần lưu ý phòng tránh!
#TayChanMieng #EV71 #DichBenh #HealthAlert #TPHMCCảnhBáo #BệnhThôngThường #VệSinhChămSóc #DịchTễ2023

https://vtcnews.vn/benh-tay-chan-mieng-lan-nhanh-o-tp-hcm-co-tre-phai-tho-may-loc-mau-ar992180.html

The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway

Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.00844-24?af=R

ABSTRACT
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria. However, the pathological damage was alleviated with the decrease of EV71 viral load. The cell experiment in vitro showed that EV71 infection significantly reduced ATP levels and promoted Schwann cell apoptosis, thus inhibiting cell growth. The extended infection time and the decreased viral load resulted in the gradual improvement of cell growth status. Meanwhile, EV71 inhibited the expression of miR-29b and promoted the expression of PMP22 in a time-dependent manner at both mRNA and protein levels, with the most significant change at 36 h of infection. Subsequently, the expression of miR-29b and PMP22 was gradually restored with the reduction of EV71 viral load. In addition, EV71 regulated the expression of hsa_circ_0069335, which could bind and co-localize with miR-29b. Therefore, EV71 infection can cause significant damage to the nervous system and may be related to hsa_circ_0069335/miR-29b/PMP22 pathway. The present study provides a new therapeutic target for neurological damage induced by EV71 infection.

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#abstract #COVID19 #encephalitis #enterovirus #ENTEROVIRUS71 #ev71 #health #HFMD #immunology #neuroinvasion #nutrition #research #wellness

The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway

Source: Journal of Virology, ABSTRACTEnterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some…

https://etidioh.wordpress.com/2024/12/05/the-neurological-damage-caused-by-ev71-infection-is-associated-with-hsa_circ_0069335-mir-29b-pmp22-pathway/