Pharma is dosing drugs wrong โ€“ the quantum tunneling correction nobody is using

https://sectio-aurea-q.github.io/pharma-dosing-error.html

#HackerNews #Pharma #Dosing #Quantum #Tunneling #DrugSafety #Innovation

Pharma Is Dosing Drugs Wrong โ€” The Quantum Error

CYP3A4 processes 50% of all oral drugs. Quantum tunneling makes it 3ร— faster than models predict. No dosing formula accounts for this.

๐‡๐จ๐ž ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ž๐ง ๐ญ๐จ๐ญ ๐ฃ๐ฎ๐ง๐ค ๐ฐ๐จ๐ซ๐๐ž๐ง ๐ ๐ž๐ฆ๐š๐š๐ค๐ญ.
Mijn verhaal โ€˜๐„๐ข๐ ๐ž๐ง ๐•๐ฎ๐ฎ๐ซโ€™ is deze week ๐ฐ๐ข๐ง๐ง๐š๐š๐ซ van ๐‡๐ž๐ญ ๐Š๐จ๐ซ๐ญ๐ž ๐•๐ž๐ซ๐ก๐š๐š๐ฅ ๐Ÿ”ฅ
Lees het hier: https://ap.lc/SUhYI|
Pijn wordt behandeld; afhankelijkheid wordt geconstrueerd.
Mijn verhaal is een aanklacht โ€” tegen stilte, recepten en een systeem dat levens herprogrammeert.
#๐๐ก๐š๐ซ๐ฆ๐š๐œ๐ข๐ž #๐Œ๐ž๐๐ข๐œ๐š๐ญ๐ข๐ž๐Œ๐š๐œ๐ก๐ญ #๐€๐Ÿ๐ก๐š๐ง๐ค๐ž๐ฅ๐ข๐ฃ๐ค๐ก๐ž๐ข๐ #๐ƒ๐จ๐ฌ๐ข๐ง๐  #๐Œ๐ž๐๐ข๐œ๐š๐ฅ๐‚๐จ๐ง๐ญ๐ซ๐จ๐ฅ #๐‹๐ข๐ญ๐ž๐ซ๐š๐ญ๐ฎ๐ฎ๐ซ #๐Š๐จ๐ซ๐ญ๐ฏ๐ž๐ซ๐ก๐š๐š๐ฅ #๐„๐ข๐ ๐ž๐ง๐•๐ฎ๐ฎ๐ซ #๐‡๐ž๐ญ๐Š๐จ๐ซ๐ญ๐ž๐•๐ž๐ซ๐ก๐š๐š๐ฅ #๐ฐ๐ข๐ง๐ง๐š๐š๐ซ Het korte verhaal
I went to look for a #dosing cup this morning, hoping to reduce mess when grinding #coffee for #espresso. And I found myself struck by an interesting detail.

When you look at product listings for dosing cups, they fall into two main groups. Group A is mostly-name-brand dosing cups priced in roughly the $25-$35 range, in either deep-drawn stainless steel or cast aluminum, with product photos showing how one would
of course use a dosing cup.

It's the other group that's interesting, in a head-scratchy way. These are mostly taper-drawn stainless steel cups from dozens of no-name brands clearly reselling the same three or four cups, for roughly $8-$15, and what is interesting about them is their product photos. Because the product photos on this tier's listings make it clear that while the vendor clearly understands that a dosing cup has something to do with coffee,
they have only the vaguest idea what it's actually for. So you have photos showing someone transferring whole coffee beans, for no apparent reason, into a dosing cup with a spoon, without a scale in sight. Or... someone pouring ground coffee from the dosing cup directly into a coffee cup. And then there's the photos where I can't quite figure out what they're trying to accomplish.

It's really kind of bizarre.

GLP1-RAs in Type 1 Diabetes: Dosing and Pharmacokinetics
As we discussed in the previous article, people are starting to use incretins as an adjunct therapy in the treatment of type 1 diabetes. All off label, of course.

Anyone familiar with these drugs will know that they are indicated to be injected once a wee
https://www.diabettech.com/glp1-ra/glp1-ras-in-type-1-diabetes-dosing-and-pharmacokinetics/
#GLP1RA #Dosing #Halflife #Mounjaro #Semaglutide #Tirzepatide #variability #WeGovy

GLP1-RAs in Type 1 Diabetes: Dosing and Pharmacokinetics | Diabettech - Diabetes and Technology

As we discussed in the previous article, people are starting to use incretins as an adjunct therapy in the treatment of type 1 diabetes. All off label, of course. Anyone familiar with these drugs will know that they are indicated to be injected once a week. A model that's easy to follow, doesn't involve too

Diabettech - Diabetes and Technology | Where Diabetes and Technology meet

Influence of #mRNA #Covid19 #vaccine #dosing interval on #risk of #myocarditis, Nat Commun.: https://www.nature.com/articles/s41467-024-52038-6

Here we show that longer intervals between each consecutive dose, including #booster, may decrease occurrence of vaccine-associated myocarditis by up to a factor of 4, especially under age 50. These results suggest that a minimum 6-month interval might be required when scheduling additional booster vaccination.

Influence of mRNA Covid-19 vaccine dosing interval on the risk of myocarditis - Nature Communications

Dosing interval has been suggested as a modifier in the risk of myocarditis associated with Covid-19 mRNA vaccination. Here, the authors show that longer intervals between each consecutive dose, including booster, may decrease the occurrence of myocarditis, especially under age 50.

Nature
3D Printed Medications Customize Dosing:
Texas A&M pharmacologists have perfected a method for 3D printing medications with precise dosages in child-friendly shapes and flavors. #3dprinting #pediatrics #bioengineering #dosing #TexasAMCC
https://www.instagram.com/p/CxL0Fo4xy_m/