Mastodawn

Maybe I should have tagged #chemsky. 18 years on social media and I still forget to use hashtags all the time

#chemsky #chemchat re: Vought/OMB rule the statement itself is judgment-less, but they are (hands waggling) talking about putting in a public comment

RE: https://bsky.app/profile/did:plc:3etshrnlom5cvnvb7udqp3zo/post/3mnhvzuprm223

Stephan Hacker May 28

Jon Stokes gave an inspiring and highly interactive @[email protected] Lecture. He talked about the power and the limitations of AI for antibiotic drug discovery. (1/4) www.thestokeslab.com #ChemSky #ChemBio #DrugDiscovery #Antibiotics #AI #MachineLearning

Stephan Hacker May 27

Interesting paper by the groups of Jongmin Park, Juyong Lee and Hankum Park in @[email protected]. They developed muscle-specific PROTACs engaging the E3 ligase KLHL41. Great to see the most potent molecules with covalent KLHL41 ligands. www.nature.com/articles/s41... #ChemSky #ChemBio #TPD

Discovery of a KLHL41 Ligand f...

Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation - Nature Communications

PROTACs rely mainly on ubiquitous E3 ligases, limiting tissue selectivity. Here, the authors identify a ligand of muscle specific E3 ligase KLHL41 and develop a covalent PROTAC (cKBD-1) that enables potent, muscle-specific protein degradation in vitro and in vivo.

Nature

Chemjobber May 27

TIL "Group 3 base oil" #chemsky Motor oil is 70%-plus, in some cases higher, Group 3 base oil. And 45% of that base oil comes out of the Middle East," Alfano said. "The largest producer of Group 3 base oil, which is Shell's Pearl GTL facility, was struck by an Iranian missile." via CBS News

Is there a motor oil shortage?...

Is there a motor oil shortage? Here's why your oil change is getting more expensive.

Certain motor oils could see shortages, and that's making oil changes more expensive.

Stephanie May 27

#chemsky 🧪⚗️ #chemchat

RE: https://bsky.app/profile/did:plc:yv5qesdlmad5db3oifduisiu/post/3mms2u7zxys2q

Chemjobber May 26

yikes #chemsky

RE: https://bsky.app/profile/did:plc:sgpikk2uv7446555gx2mawpz/post/3mmrisnz23k2z

Chemjobber May 24

man, this is really disappointing that no one came up (so far as I can tell) with the correct chemical - it's phenothiazine (PTZ), as demonstrated in the Dow users guide for methacrylate esters: www.dow.com/en-us/docume... #chemsky

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Nessa Carson May 24

What is "hydrogenated styrene/butyric acid copolymer"? Seen on skincare patch ingredient list. I can't imagine making a copolymer of those two things and having much left to hydrogenate. Perhaps it's the carbonyls somewhere? #chemsky

Well-tarred Flask 🇮🇹🇺🇦🇨🇦May 23

Er. Seriously praying for a benign outcome, but needing foam vs water to put out a potential fire is not a methyl methacrylate thing -- that's just a burning pool of generic liquid thing... #ChemSky