@lizziewriter

I was just thinking this morning that ppl may be getting misdiagnosed w/ chronic Lyme when they have LC or ME. This is concerning since off-label use of disulfiram (Antabuse) is being becoming popular for chronic Lyme. Risk/benefit may be favorable for disulfiram for glioma or Lyme carditis, but I have misgivings about its use in other contexts due to suicide risk. Also, malondialdehyde levels are already elevated in LC.

#disulfiram #DrugRepurposing
#Lyme #LymeDisease

“She was given Antabuse to treat her alcoholism, but an autopsy upon her death (which was due to falling from a window, not cancer) revealed that her body was clinically cancer-free despite having no further cancer treatment.”

She fell from a window. 🤔

https://www.newsweek.com/cancer-treatment-drug-alcoholism-antabuse-742864

#disulfiram #CarbonDisulfide #DrugRepurposing #SideEffects

This Extremely Common Drug Given to Alcoholics Also Kills Cancer Cells, and We Finally Know Why

Scientists have finally figured out why the common alcoholism medication benefits cancer patients.

Newsweek
#disulfiram #COVID19
Another armchair research interest of mine is the use of repurposed medications in Covid.
After the first suggestions that disulfiram, the well known aversive drug for alcohol dependence, could antagonize SCV2 protease, we looked at Covid symptoms in disulfiram-treated patients, during 1st wave in Italy. Here's our observational study.
(Today I believe its effect is mainly due to inhibition of pyroptosis and NETosis).
RCTs are ongoing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814518/
COVID-19 and related symptoms in patients under disulfiram for alcohol use disorder

PubMed Central (PMC)