Alberto CicciaDec 23, 2022

Exciting to see that the base editing strategies for gene inactivation that Pierre Billon in our lab and the Adli lab contributed to develop have been useful to engineer T cells for the treatment of a patient with T-ALL! #iSTOP #CRISPRSTOP #GenomeEditing #CRISPR #cancer

World-first use of base-edited cells to treat ‘incurable’ leukaemia
https://www.ukri.org/news/world-first-use-of-base-edited-cells-to-treat-incurable-leukaemia/#:~:text=A%20patient%20with%20'incurable'%20T,acute%20lymphoblastic%20leukaemia%20in%202021

Base-edited CAR T cells for combinational therapy against T cell malignancies
https://www.nature.com/articles/s41375-021-01282-6

World-first use of base-edited cells to treat ‘incurable’ leukaemia

A patient with ‘incurable’ T-cell leukaemia has been treated with base-edited T-cells in the world’s first reported use of a base-edited therapy.