The hydrophobicity of the
#CARD8 N-terminus tunes
#inflammasome activation by @LydiaTsams, @DBachovchin, and colleagues at @MSKCancerCenter @WeillCornellGS @TPCB_NYC
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00223-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodonOnline now! The hydrophobicity of the
#CARD8 N-terminus tunes
#inflammasome activation by @LydiaTsams, @DBachovchin, and colleagues at @MSKCancerCenter @WeillCornellGS @TPCB_NYC
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00223-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #chembiolInnate immune
#CARD8 mechanism for sensing
#coronavirus &
#picornavirus infection by detecting activity of
#virus-encoded proteases; genetic variants in mammalian hosts affect which viruses can be sensed @BriBerryTea
@psmitchej @Daugherty_Lab
#PLOSBiology https://plos.io/43S8JZk
Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
This study describes an innate immune mechanism for sensing coronavirus and picornavirus infection by detecting the activity of virus-encoded proteases. Genetic variants among mammalian hosts affect which viruses can be sensed by this host ‘tripwire’ system, confirming its importance in the evolutionary arms race between viruses and the host immune response.
Cell Chemical Biology
PLOS Biology