It's very sad, but it's always a damn waste of time reading academic research about binary diffing or, as it's called at the academia, about binary code similarity analysis. It's either all fairytales that cannot be proved or, plainly, false and/or wrong.
An example? One paper that I have re-read today says that #BinDiff and #Diaphora are mono-architecture and totally discard these tools for the paper. LOL.