Silvana Novelli

@snovelli
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64 Posts
Hematologist. #Lymphoma and #immunotherapy #ITP #hematology - Institut Català d’Oncologia
Sometimes I #tapdance with the queen!
#ZUMA2trial for highly refractory MCL (including BTKi) has a 93% ORR, 67% CR.
These ITT population within DESCAR-T had an 84.7 ORR, with 72.2% CR (median FU 14.2 m). mOS 19.8 m mPFS 9.5.
https://haematologica.org/article/view/haematol.2023.284786
Brexucabtagene autoleucel in relapsed or refractory mantle cell lymphoma, intention-to-treat use in the DESCAR-T registry | Haematologica

STOP Herpes
🦠Mye: APL risk 11.6-45.7 MPN w Ruxo 3.5 to 6.9 cases per 100 patient-years. Acyclovir
🦠 Lym: vaccine with anticipation, then prof w Acyclovir
🦠MM, vaccine if proteasome inh is planned, then prof w Acyclovir
🦠 ASCT, SCT, CART always Acyclovir, follow protocols
https://haematologica.org/article/view/haematol.2023.284417
Towards personalized prevention of Herpes zoster infection in patients with hematologic diseases or hematopoietic stem cell transplant recipients: a position paper from an <I>ad hoc</I> Italian expert panel | Haematologica