Silvana NovelliNew Phase 3 data for Romiplostim in Chemo-Induced Thrombocytopenia
✅ 84% of pts on Romiplostim maintained full chemo dose/schedule vs. 36% for placebo (OR 10.16).
✅ Targeted GI cancers (CRC, Gastric, Pancreatic).
✅ Low rate serious AEs.
#Oncology #Hematology www.nejm.org/doi/full/10....
Silvana Novelli
@snovelli
- 34 Followers
- 126 Following
- 64 Posts
Continuous vs. Fixed-Duration in CLL? The Phase 3 CLL17 results are in:
📊 3-Year PFS (Noninferior):
• Ven+Obi: 81.1%
• Ven+Ibru: 79.4%
• Continuous Ibru: 81.0%
Undetectable MRD:
Ven+Obi leads the pack at 73.3%, vs 0% for continuous ibrutinib.
www.nejm.org/doi/full/10....
nejm.org/doi/full/10.10...
nejm.org/doi/full/10.10...
CAR-T is effective for older adults, but neurotoxicity monitoring is key.
✅ Older age does not worsen overall survival or PFS.
✅ Relapse risk was actually lower in the 65–74 age group (HR 0.77).
⚠️ ICANS risk increases with age (HR 1.03 per year).
www.sciencedirect.com/science/arti...
STITCHES MedicineBCMA CAR-T therapy achieves 100% minimal residual disease negativity in newly diagnosed multiple myeloma patients unsuitable for stem-cell transplantation.
by Yan W, Du C (...) An G et 16 al. in J Clin Oncol
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01969
Hans IHC discrimination of Cell-of-Origin Subtype is a valid method for predicting Polatuzumab response in DLBCL aacrjournals.org/clincancerre...
Cell-of-Origin Subtype Predict...
Cell-of-Origin Subtype Predict...
Should we start seeking clonal hematopoiesis before B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy? aacrjournals.org/clincancerre...
Clonal Hematopoiesis and Infla...
Clonal Hematopoiesis and Infla...
mandy brown“To be a Luddite today is to refuse the fatalism of techno-inevitability & to demand that technology serve the many, not the few. It is to assert that questions of labor, agency & justice must come before speed, efficiency & scale.” https://www.brookings.edu/articles/we-should-all-be-luddites/
Now it is imperative to include CLIPI in the routine evaluation of advanced stages Mycosis Fungoides & Sézary syndrome; especially when considering for alloSCT #ctcl
ashpublications.org/blood/articl...
A new prognostic index (CLIPI)...
A new prognostic index (CLIPI)...
Lo mejor de escuchar a otros especialistas es cuando te encuentras con inmunólogas como la Dra. Silvia Vidal y te da una clase de #XPO #selinexor en el #mieloma
#Hemato2025 @sehhematologia.bsky.social
“Manejo periquirúrgico de los pacientes con coagulopatías adquiridas inmunológicas” con Eva Mingot, un enfoque práctico. @hospitaluvrocio.bsky.social @sehhematologia.bsky.social #Hemato2025
