Scholpp_Lab

@[email protected]
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13 Posts
We are interested in cell-cell communication, morphogens, Wnt signalling, zebrafish, cancer, neurodegenerative diseases and cytonemes.
https://biosciences.exeter.ac.uk/staff/profile/index.php?web_id=Steffen_Scholppscience
zebrafishWnt signalling
gastric cancerdevelopmental biology
cell biologyacademia
Show threadScholpp_LabAug 15, 2024
@amjeve @CellySally @jamesbriscoe @Co_Biologists ok, I did not know that. I will try to move my account to this server. Wish me luck!🤓
Scholpp_LabAug 15, 2024
Now, I have some questions: I wondered how to find and connect to all the fantastic and inspirational scientists if they are based on other servers. I found some, like @CellySally, @jamesbriscoe, and @amjeve. Did I start my account on the wrong server? Where are the other cell and dev biologists from the UK? I would like to read about cool new publications/preprints. Thanks.
Scholpp_LabAug 15, 2024
It took me some time, but the latest events on Twitter made it obvious to me that this is not a platform that I want to support. Therefore I moved to mstdn.
Scholpp_LabAug 15, 2024
Excited to be on my way to #IZFC2024 #zebrafish #izfs2024 #izfs. Looking forward to lots of cool discussions about signalling, Wnt, and zebrafish! And meeting lots of zebbie friends and colleagues. Kyoto, here we come!
Show threadScholpp_LabAug 14, 2024
@CellySally @IanSudbery Excellent point, Ian. However, I am unaware of evidence that mechanical signals can assign a specific "competence" to a cell, e.g., to acquire a particular cellular fate—similar to morphogens. Please correct me if I am wrong. I am a big fan of the idea that cells integrate mechanical and chemical stimuli to achieve a specific outcome. The only evidence I could find is a recent publication from the Mayor lab: https://www.nature.com/articles/s41556-024-01378-y.
Competence for neural crest induction is controlled by hydrostatic pressure through Yap - Nature Cell Biology

Alasaadi et al. report the role of hydrostatic pressure in regulating embryonic competence in the developing neural crest.

Nature
Show threadScholpp_LabAug 14, 2024
@CellySally I agree with everything you said. However, could a cell react without the external trigger of a chemical signal? And how could this cell react if it would not express the appropriate receptor for signal integration? Everything else will follow. #morphogen #morphogenesis #DevBio
Scholpp_LabAug 13, 2024
Here are the articles: https://pubmed.ncbi.nlm.nih.gov/37722040/ and here: https://pubmed.ncbi.nlm.nih.gov/38123680/ Let me hear what you think?
Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2 - PubMed

Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor microenvironment influencing cancer progression. Besides shaping the extracellular matrix, these fibroblasts provide signaling factors to facilitate tumor survival and alter tumor behavior. In gastric cancer, one crucial signa …

PubMed
Scholpp_LabAug 13, 2024
Have we just challenged the long-standing concept of Waddington and Spemann? Or do we need an extended model?
Scholpp_LabAug 13, 2024
What happens if a cell receives receptors via cytonemes - can it acquire a new competence? Adopt a competence? Can this adoptive competence override the innate competence?
Show threadScholpp_LabAug 13, 2024
Therefore, competence is foremost defined by the availability of the appropriate receptor to be able to respond to a particular signal (ability to react).