Pyotr Ilyich Tchaikovsky - Swan Lake - Valse
Great White Shark - Oahu, Hawaii
Is your research described by one of these: #popgen, evol. #genomics/#epigenetics, #life-histories, #biotic interactions, eco-evolutionary dynamics, long-term #field studies, #anthropology?
Come and make us stronger! Full #professorship at Uni #Mainz. Lots of recent turnover has happened here with fantastic young faculty, we have a lot of exciting plans for the future!
https://karriere.uni-mainz.de/university-professor-of-evolutionary-biology/
Deadline 28 June!
@ecoevojobs
Los invito a ver el teaser del documental “El espíritu de nuestro mar” del colectivo “El pueblo es el mar” de la ONG “#SomosOceanos” espero sea de su agrado y en cuanto esté listo el documental se los haré saber… Saludos desde La Paz Baja California Sur!!
The high selectivity shown by conotoxins for ion channels and receptors could allow their use as drugs to treat different neuropathies. The most notable example to date is the drug Ziconotide. This compound is the synthetic form of the w-conotoxin MVIIA, from Conus magus, which blocks N-type calcium channels. Ziconotide was evaluated as a drug to block chronic pain in patients with terminal cancer and AIDS, and its potency and effectiveness are greater than other analgesic drugs (it is a thousand times more powerful than morphine) and does not cause addiction. Ziconotide was approved in the third stage of its clinical evaluation, determined by the Food and Drug Administration of the United States, and has begun to be marketed publicly under the name of Prialt.
Other conopeptides with pharmaceutical potential are conantokines, discovered by the group led by Dr. Baldomero Olivera, a researcher of Filipino origin who pioneered the study of Conus venoms. The word conantokina is derived from the Filipino word, antokin –which means sleep–, because when these peptides are injected directly into the brain of mice, it produces this effect. Conantokinas are blockers of certain glutamate receptors (NMDA type). These receptors play a very important role at the level of the fish sensory system and in memory processes, learning and epileptic disorders in mammals. Conanthokines are currently being used in preclinical studies for the treatment of epilepsy in the United States, where 2.3 million people suffer from this disorder.
As can be seen, conotoxins constitute a powerful tool in the study of the molecules on which they act, since they help to define the events and molecular mechanisms in which they are involved. For example, it was recently shown, using the ?-MrIA and ?-MrIB toxins from Conus marmoreus, that transporters (proteins responsible for recapturing neurotransmitters) constitute a new type of molecular target for conotoxins. The toxins? have a blocking effect on the norepinephrine transporter.