Vaughan & Stadler develop a method to infer multitype population trajectories and apply it to MERS-CoV, revealing transmission patterns between camels and humans.

🔗 doi.org/10.1093/molbev/msaf130

#evobio #molbio #virus

Is MEGA-GPT heralding a new age of accessibility in bioinformatics with dedicated chatbots to help guide users? Read more in MBE's new Highlight: "MEGA into the New Generation of Computational Genetics"

🔗 doi.org/10.1093/molbev/msaf108

#evobio #molbio #bioinformatics #AI

Using an experimental evolution platform @farhanrc.bsky.social & @chemtips.bsky.social show that tripartite antibiotic loops - sequential regimens involving three antibiotics - can resensitize bacteria to the 1st drug as multidrug resistance evolves

🔗 doi.org/10.1093/molbev/msaf115

#evobio #molbio

Jesse Bloom argues that the earliest available sequences of SARS-CoV-2 are not fully representative of actual early cases.

🔗 doi.org/10.1093/molbev/msaf118

#evobio #molbio #covid19 #sarscov2 #publichealth

Florence Débarre and Zach Hensel‬ offer a new perspective on available SARS-CoV-2 sequencing data, in particular regarding the earliest reported sequences.

🔗 doi.org/10.1093/molbev/msaf109

#evobio #molbio #covid19 #sarscov2 #publichealth

Yaddehige et al. present GBRAP, a parser and database for analyzing RefSeq genomes. This publicly available tool offers over 200 metrics per genome element with flexible retrieval, visualization, and export options.

🔗 doi.org/10.1093/molbev/msaf114

#evolbio #molbio #bioinformatics

John Allard‬ & Sudhir Kumar introduce MEGA-GPT, an AI assistant that aims to improve the usability of the feature-heavy MEGA software by guiding users through MEGA's options via natural language queries.

🔗 https://doi.org/10.1093/molbev/msaf101

#evobio #molbio #bioinformatics

Jones et al. investigate gene regulation in the social supergene of the fire ant, finding widespread impacts on chromatin accessibility, enhancer activity, and transcription.

🔗 doi.org/10.1093/molbev/msaf112

#evobio #molbio #bugsky

The June cover of Molecular Biology and Evolution features the work of de Bakker et al., who studied the developmental genetics of amniote limb phenotypes.

🔗 doi.org/10.1093/molbev/msaf113

📷 Gerda Lamers

#evobio #molbio #evodevo

Thompson et al. model gene expression as a binary trait to examine transcriptome turnover across Drosophila species, inferring gains and losses of organ-specific expression.

🔗 doi.org/10.1093/molbev/msaf106

#molbio #evobio #transcriptomic #drosophila