Understanding the kinetics of GPCR signalling seems like one of the most important challenges still...

https://www.science.org/doi/10.1126/sciadv.abq3363

Wondering how accurate #AlphaFold models are?

We compared #AlphaFold predictions with experimental data. Many parts are great, but even high-confidence #AlphaFold predictions have distortions, domain movements, backbone errors, and side chain errors.

https://www.biorxiv.org/content/10.1101/2022.11.21.517405v1

'We have developed OpenFold, a complete open-source reimplementation of AlphaFold2 that includes training code and data. By training OpenFold from scratch and matching the accuracy of AlphaFold2, we have demonstrated the reproducibility of the AlphaFold2 model for protein structure prediction. Furthermore, the OpenFold implementation introduces technical advances over AlphaFold2, including markedly faster prediction speed.'

https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1?med=mas

RT @[email protected]

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RT @[email protected]

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🐦🔗: https://twitter.com/chrismichel/status/1595143003605069824