katja heuer

720 Followers
460 Following
88 Posts
into brain development & evolution, open science, art & science https://www.youtube.com/watch?v=6hMNZHsrNHw, music, making, javascript, contemporary dance https://www.youtube.com/watch?v=OZfHj7F2FzQ
Art of MRhttps://www.youtube.com/watch?v=6hMNZHsrNHw&t=6s
websitehttps://katjaq.github.io

@r3rt0 @AleAliSousa @sofievalk

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We work collaboratively online! Please reach out and come join us at any time! ❤️ 🐒 🐒 🐒

@r3rt0 @AleAliSousa @sofievalk

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Comparing the allometric relationships between section length and area suggests that a similar process lies behind the folding of the cerebrum and the cerebellum, that can be explained by buckling and where wavelength of folding depends on cortical thickness.

@r3rt0 @AleAliSousa @sofievalk

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Our results confirm the strong correlation between cerebral and cerebellar volumes across species, and we extended these results to show that the same strong relationship holds for cerebellar folding: larger cerebella appear to be disproportionately more folded than smaller ones.

@r3rt0 @AleAliSousa @sofievalk

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Folial width, folial perimeter and the thickness of the molecular layer increase slightly with cerebellar size, largely conserved when compared with changes in total cerebellar size, as revealed by the small allometric slopes.

@r3rt0 @AleAliSousa @sofievalk

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The cerebellar and cerebral cortices are disproportionately larger than their volumes, as shown by their hyper-allometry. The cerebellum is slightly but statistically significantly hypo-allometric compared to the cerebrum.

@r3rt0 @AleAliSousa @sofievalk

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Cerebellar size and folding correlate strongly with cerebral size and folding.
Ancestral character state estimations showed that size and folding of the cerebrum and cerebellum increase and decrease concertedly through evolution.

@r3rt0 @AleAliSousa @sofievalk

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Phylogenetic comparative methods revealed that the evolution of cerebellar and cerebral neuroanatomy follows a stabilising selection process.

@r3rt0 @AleAliSousa @sofievalk

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We used our Web tool MicroDraw to visualise and segment the histological data online, and created tools to study the geometry of cerebellar folia and to estimate the thickness of the molecular layer.

🧠🐒🐐🦘🦙🦌🐷🐻‍❄️🦫🦁🐑🐇🐈🦔🐕🦇🦭🦥🦓
We’ve been diving into the mesmerising anatomical diversity and evolution of cerebellar folding across 56 mammalian species with @r3rt0 Nicolas Traut @AleAliSousa @sofievalk
https://www.biorxiv.org/content/10.1101/2022.12.30.522292v1

Check it out in a short tooting thread 🔽