anne.đź’«Today is the 25th anniversary of Deus Ex.
I adore that game so much...I might spin it up today. It's been awhile. :)
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Benjamin
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#Bioinformatics, Coding (#Rust, #Python #R), Statistics, Microbial genomics and #Metagenomics, biology. Views don't represent my employer.
This is great and sums up many of my thoughts on this “ai” moment
https://hackers.town/@GeoffWozniak/114213465822506806
https://hackers.town/@GeoffWozniak/114213465822506806
Geoff Wozniak (@[email protected])
"Why is sentience even a goal?" https://netsettlement.blogspot.com/2025/03/sentience-structure.html
daniel:// stenberg://It's time to re-enjoy this golden quote about me and #curl, shown in the most awesome way.
Colin D
We also examined his biogeography and attempted to ascertain where he may have originated from.
We found he is related to other sequenced Aldabra tortoises, but he has a contribution from an unknown source.
Our new preprint: "Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan".
Jonathan is estimated to be at least 192 years old - the oldest known terrestrial animal. In this study we examine his genome and epigenome and found changes that may help explain his extreme longevity.
https://www.biorxiv.org/content/10.1101/2025.02.05.636284v1.full
Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan
Giant tortoises exhibit exceptional longevity, often exceeding the human lifespan. To understand the genomic and epigenomic basis of their longevity, awe analyzed the DNA sequence and methylome of Jonathan, an Aldabra giant tortoise (Aldabrachelys gigantea), estimated to be 192 years old. Relative to other giant tortoises (Aldabrachelys gigantea and Chelonoidis abingdonii), we found Jonathan has gene variants in pathways associated with aging, including DNA repair and telomere regulation. Consistent with his advanced age, Jonathan has significant age-related changes in DNA methylation and methylation entropy, compared with a 5-year-old Aldabra individual. Notably, we found that low entropy regions in Jonathan’s methylome were enriched for genes involved in the electron transport chain. This suggests that high-fidelity transcription of these genes may be crucial for extreme longevity. With this data, we propose a model for aging, that links efficient mitochondrial energy production with nuclear maintenance of low methylation entropy. ### Competing Interest Statement The Regents of the University of California are the sole owner of patents and patent applications directed at epigenetic biomarkers for which Steve Horvath is a named inventor; SH is a founder and paid consultant of the non-profit Epigenetic Clock Development Foundation that licenses these patents. SH is a Principal Investigator at the Altos Labs, Cambridge Institute of Science. The other authors declare no competing interests.
GSV Megastructure EnthusiastIt's a complicated world; things we thought we could count on forever are falling by the day. Take solace in the one immutable fact of the universe:
Oracle are the biggest shitheads on earth.
Erik Uden 🍑 (@[email protected])
Attached: 1 image This is a public service announcement to **never** ever use Oracle
Mike OlsonOne of my favorite podcasts is Oxide and Friends by @bcantrill and @ahl. The episode on Intel after Gelsinger was excellent:
https://oxide-and-friends.transistor.fm/episodes/intel-after-gelsinger
Bryan and Adam talk at length about deep cultural inertia at Intel and how it's stymied the company's efforts to maintain its leadership position in the market.
They make some interesting and very specific recommendations about how a new CEO ought to change the company to meet the moment.
1/2
Zeke HausfatherGreat (and scary) visualization of 2024 daily temperatures compared to prior years by the BBC today. Evocative of the iconic Joy Division album cover from 1979: https://www.bbc.com/news/articles/cd7575x8yq5o
David Sirota“There are three elements that fuel our fulfillment: relationships, service, and purpose (but) many of the messages coming at us tell us to prioritize a different triad, the triad of success: fame, wealth, and power.” https://people.com/surgeon-general-vivek-murthy-americans-closing-letter-rethink-how-we-are-living-our-lives-exclusive-8770191
