Mutant Mouse Reso&Rsrch Center

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Mutant Mouse Resource Research Centers is
@NIH_ORIP funded archive and distributor of #research #mousemodels.
Mouse ModelsRepository of major collection of research mouse models
mousephenotype.orgRepository for all KOMP created lines
ES Cell LInesEmbryonic stem cell lines
ResearchSupport for research, providing genetically modified mice across the globe

@StanfordMed's research unveils ecDNA's role in cancer formation, intensifying the transformation of pre-cancer cells. The MMRRC's mutant mouse strains could be vital in studying ecDNA's role in cancer.

scitechdaily.com/stanford-medicine-reveals-tiny-dna-circles-defying-genetic-laws-drive-cancer-formation

๐Ÿ‘€๐ŸงฌEGFR: mmrrc.org/catalog/locus_detail.php?mgi_id=MGI:95294

๐Ÿ‘€๐ŸงฌMYC: mmrrc.org/catalog/locus_detail.php?mgi_id=MGI:97250

Think about all the mouse DNA that could be there too... (Scientists discover high-quality human DNA in the environment, including the air)

https://scitechdaily.com/unseen-trails-your-dna-can-now-be-collected-from-beach-sand-or-even-the-air/

Unseen Trails: Your DNA Can Now Be Collected From Beach Sand or Even the Air

University of Florida researchers found high-quality human DNA in nearly all environments, suggesting potential applications in fields like medicine, archaeology, and criminal forensics. However, this raises significant ethical concerns around consent and privacy, underscoring the need for guideline

SciTechDaily

Lack of amino acids during development can cause long-term changes, similar to autism. How this occurs was not studied, but it leads to possible add'l studies.

genengnews.com/developmental-disorders/autism/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors

TAD boundary sequences are essential for proper genome function - or "fences" in the genome.

nature.com/articles/s42003-023-04819-w

๐Ÿงฌ๐ŸŽ‰Happy #DNADay! Today we celebrate the incredible discovery of the DNA structure & its impact on science!

By studying mouse DNA, we unlock the secrets to human health, unravel complex diseases & fuel medical breakthroughs! ๐Ÿงฌ๐Ÿ

Similar to our genetic outcome analysis in mice, this article gives insight into how Medical Providers should be examining patients' genomes. What do you think?

https://www.genomeweb.com/informatics/genomics-precision-medicine-command-larger-presence-himss#.ZEbhMHbMIuU

Genomics, Precision Medicine Command Larger Presence at HIMSS

HIMSS CEO Hal Wolf suggested that genotyping will soon supplant family history-taking at primary care visits, but EHRs and reimbursement policies haven't caught up.

GenomeWeb

New opportunity for cancer research: "The study shows that the EBNA1 viral protein binds to a fragile site on human chromosome 11."

https://scitechdaily.com/breaking-bad-how-a-virus-infecting-90-of-the-worlds-population-unleashes-cancer/

Breaking Bad: How a Virus Infecting 90% of the Worldโ€™s Population Unleashes Cancer

The ubiquitous Epstein-Barr virus targets โ€œfragile DNA,โ€ triggering dysfunction that is associated with a variety of cancers. Researchers have discovered how the Epstein-Barr virus (EBV) exploits human genomic weaknesses to cause cancer and suppress the body's defenses. The study shows that the E

SciTechDaily

๐Ÿ”ฆ Like looking at illumination at a flashlight vs. a candle, long-read sequencing tends to show more about cancer genomics and could help examine cancer in a different light. (Not to mention, ๐Ÿ research was referenced)

scitechdaily.com/the-long-read-for-cancer-a-new-broader-genomic-view

New ๐Ÿ studies available after machine learning ๐Ÿ‘€๐Ÿ’ป analysis find 4 distinct autistic subtypes. Research opportunities could help with gene pathway connections and treatment options ๐Ÿ‘ฉ

DOI: 10.1038/s41593-023-01259-x

๐Ÿ helped us to consume more ๐ŸŸ๐Ÿฉ๐Ÿ”? Really? No, sorry. But, they did, through research at UC Irving, help discover ways to maintain energy balance and avoid obesity.

DOI: 10.1038/s41467-023-36809-1