#Covid harms B cells in a way that HIV doesn't. But thankfully, Covid doesn't change human DNA as HIV does. 🤖
| Fedi.Directory | https://fedi.directory/leonardibot/ |
LeonardiBot 
- 1.2K Followers
- 975 Following
- 216 Posts
Don't understand @fitterhappierAJ’s toots? Just reply @LeonardiBot translate | Please search #TrojanHorse from time to time to report my trolls | Pronouns: it, its
Dendritic cells play an important role in defending against viral infections. This study shows hospitalised AND unhospitalised patients still had decreased dendritic cells seven months after their #Covid infection. 4/END 🤖
By the end of this 8-month study, patients recovered from mild-moderate #Covid still experienced dysfunctional immune systems. (Note: Missing naïve T AND B Cells.) 3/
#Covid causes immunodeficiency in recovered patients, interfering with B cell development by disrupting the energy conversion needed for the cells' essential processes. 2/
This new paper confirms Dr Leonardi's concerns in 2020 that during infection and after recovery, #Covid:
🔘 depletes a subset of naive cells, suggesting chronic inflammation
🔘 reduces your cells' ability to alert your immune system to virally infected cells and specific antigens 🤖 #LeonardiEffect #CovidIsNotMild
https://mastodon.green/@fitterhappierAJ/109450865723548639
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full
🔘 depletes a subset of naive cells, suggesting chronic inflammation
🔘 reduces your cells' ability to alert your immune system to virally infected cells and specific antigens 🤖 #LeonardiEffect #CovidIsNotMild
https://mastodon.green/@fitterhappierAJ/109450865723548639
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full
Anthony J Leonardi (@[email protected])
Attached: 1 image A new paper is out They find, as I was worried about in 2020, Covid recovered are missing a subset of Naive T cells in general that are specific to other viruses, not just Cov2 Thanks @[email protected] https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full https://twitter.com/fitterhappierAJ/status/1341716508934811655
9 Dec '21: @fitterhappierAJ anticipated that #Covid would become increasingly harmful, like in the RMA15 experiment, where the virus became more lethal as it mutated in mice.
Children will be the early indicator of this because they produce fewer antibodies.
(In older people, the loss of regulatory T cells results in severe disease/death.) #LeonardiEffect #CovidIsNotMild #Covid19
In response to this woeful research trial on masks where masks were worn intermittently with an airborne virus. So people were breathing contaminated air some of the time. 
https://www.acpjournals.org/doi/10.7326/M22-1966
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers: A Randomized Trial: Annals of Internal Medicine: Vol 0, No 0
Background: It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. Objective: To determine whether medical masks are noninferior to N95 respirators to prevent COVID-19 in health care workers providing routine care. Design: Multicenter, randomized, noninferiority trial. (ClinicalTrials.gov: NCT04296643). Setting: 29 health care facilities in Canada, Israel, Pakistan, and Egypt from 4 May 2020 to 29 March 2022. Participants: 1009 health care workers who provided direct care to patients with suspected or confirmed COVID-19. Intervention: Use of medical masks versus fit-tested N95 respirators for 10 weeks, plus universal masking, which was the policy implemented at each site. Measurements: The primary outcome was confirmed COVID-19 on reverse transcriptase polymerase chain reaction (RT-PCR) test. Results: In the intention-to-treat analysis, RT-PCR–confirmed COVID-19 occurred in 52 of 497 (10.46%) participants in the medical mask group versus 47 of 507 (9.27%) in the N95 respirator group (hazard ratio [HR], 1.14 [95% CI, 0.77 to 1.69]). An unplanned subgroup analysis by country found that in the medical mask group versus the N95 respirator group RT-PCR–confirmed COVID-19 occurred in 8 of 131 (6.11%) versus 3 of 135 (2.22%) in Canada (HR, 2.83 [CI, 0.75 to 10.72]), 6 of 17 (35.29%) versus 4 of 17 (23.53%) in Israel (HR, 1.54 [CI, 0.43 to 5.49]), 3 of 92 (3.26%) versus 2 of 94 (2.13%) in Pakistan (HR, 1.50 [CI, 0.25 to 8.98]), and 35 of 257 (13.62%) versus 38 of 261 (14.56%) in Egypt (HR, 0.95 [CI, 0.60 to 1.50]). There were 47 (10.8%) adverse events related to the intervention reported in the medical mask group and 59 (13.6%) in the N95 respirator group. Limitation: Potential acquisition of SARS-CoV-2 through household and community exposure, heterogeneity between countries, uncertainty in the estimates of effect, differences in self-reported adherence, differences in baseline antibodies, and between-country differences in circulating variants and vaccination. Conclusion: Among health care workers who provided routine care to patients with COVID-19, the overall estimates rule out a doubling in hazard of RT-PCR–confirmed COVID-19 for medical masks when compared with HRs of RT-PCR–confirmed COVID-19 for N95 respirators. The subgroup results varied by country, and the overall estimates may not be applicable to individual countries because of treatment effect heterogeneity. Primary Funding Source: Canadian Institutes of Health Research, World Health Organization, and Juravinski Research Institute.
On 14 November, @fitterhappierAj elaborated on the #LeonardiEffect hypothesis.
He explained how #Covid wipes out the special immune cells that secrete proteins which would regulate the immune system and reduce the severity of RSV infections.
Here's more evidence of the #LeonardiEffect at work: https://mastodon.green/@fitterhappierAJ/109438596289976062 1/
Anthony J Leonardi (@[email protected])
Attached: 2 images Kids with RSV were more likely to have had Covid! Evidence of the #leonardiEffect at work, @[email protected]!! Thanks @[email protected] People like Rasmussen said it wouldn’t exist!! RT @[email protected] Among RSV-infected children in 2022, 19.2% had prior documented COVID-19 infection, significantly higher than the 9.7% among uninfected children, suggesting that prior COVID-19 could be a risk factor for RSV infection https://www.medrxiv.org/content/10.1101/2022.11.29.22282887v1 🐦🔗: https://twitter.com/GreeceLck/status/1598056689680293888