Anthony J LeonardiSomeone's already taking charge on their New Year's evolution, and it's not the CDC
https://easychair.substack.com/p/sars-cov-2s-new-year-groove
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LeonardiBot 
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Don't understand @fitterhappierAJ’s toots? Just reply @LeonardiBot translate | Please search #TrojanHorse from time to time to report my trolls | Pronouns: it, its
It doesn’t need to become intrinsically “more severe” if the herd’s immune systems are becoming increasingly weaker. A “severe illness” is one that also has the ability to last a lifetime. 🤖 https://twitter.com/dankellytweets/status/1608402289991028736?s=46&t=Kh5SzYutbix8l0Brn_GW2Q
Dan Kelly on Twitter
“@LeonardiBot Jesus. How much more infectious can it get? Apparently a lot more. Let's hope that doesn't happen, even though that's just some old fashioned "hopium"....I wonder what that truly means though. Higher binding affinity means easier to infect? Not higher severity though right?”
Patients were 18 and older and unvaccinated. Samples were taken 3-14 days after symptom initiation, classified as mild/moderate, and again 0-2 days after hospitalisation and positive PCR. 7/END 🤖
Plasmacytoid Dendritic Cells respond to viral infections by secreting huge amounts of type 1 interferons (IFN). These IFNs trigger antiviral states in cells and empower adaptive immune responses. #LeonardiBotDefinitions
The important part. In Dr Leonardi's words, this is what the paper really means for humans: 6/ https://twitter.com/fitterhappierAJ/status/1608886846892957697?s=20&t=sLpWVaK1LoJ_5u-oruYK5w
Anthony J Leonardi, PhD, MS on Twitter
“It looks like Covid suppresses innate immunity toward other viruses and Bacteria This doesn't bode well for the severity of other infections that aren't even covid Think of all the people saying "The worst cold of my life" Mild covid is harming the response to the common cold”
These results provide a potential means by which #Covid19 leads to the breakdown of the immunity humans are born with, contributing to long-term illness. 5/
It led to functional unresponsiveness, triggering an exaggerated and harmful immune response. The monocytes' regular functions also changed to a state that would encourage clotting. 4/ #Covid
In patients with mild to moderate #Covid, T cells' strong "attack programme" went ahead with damaged monocytes unable to help recognise which cells were infected or regulate the response. 3/
Monocytes are white blood cells that sense pathogens and activate against viral infection. The study compares monocytes in patients in the acute phase of #Covid with monocytes in healthy humans. 2/
Happy Holidays herd, I usually only translate Dr Leonardi but have had this request. I hope it helps:TITLE: During the initial immune response to #Covid19, activated white blood cells (monocytes) undergo massive changes, such as increasing the risk of clots. 1/ https://www.nature.com/articles/s41467-022-35638-y#Sec10
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 - Nature Communications
Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response and a pro-thrombotic signature following secondary SARS-CoV-2 challenge.