Obesity confers #macrophage memory

◽️Obesity triggers #epigenetic reprogramming of the innate immunity, lasting long after return to normal weight

◽️Stearic fatty acid (via TLR4) remodels chromatin & ↑AP-1 accessibility

◽️MΦ shift OXPHOS→ glycolysis

https://science.org/doi/10.1126/science.abj8894