Is you dmesg filling up with apparmor "DENIED" messages?
Mine was full of such from the profiles 'ubuntu_pro_esm_cache' and 'ubuntu_pro_apt_news' trying to open libraries (via python3) in non-system locations.
The solution is to add the corresponding profile override to '/etc/apparmor.d/local/', like so:
$ cat ubuntu_pro_apt_news
/opt/local/lib64/* rm,
@{HOME}/local/lib/* rm,
These are then included by ../<profile_name> and the 'errors' go away.