SBGridSBGrid's eLife paper received a citation in February from Oriana F. from Wesleyan University and Titus Boggon from Yale University in Nature Communications: Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.
Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression - Nature Communications
Loss of KRIT1 or CCM2 drives harmful KLF4 overexpression in brain vessels. Here, authors show a single KRIT1 must recruit two CCM2 proteins via dual PTB-NPxF interactions to suppress KLF4, revealing a previously unknown PTB clustering mechanism.