Coffee has never been proven harmful, and may be protective for the brain. I quit caffeine a couple times when younger for months and (once past the initial withdrawal headache) all that happened was I got more migraines and gained a couple of pounds, saw no benefits.

So no.

Alcohol I practice moderation, once or twice a week but never, ever, ever an everyday drinker. That I’ve taken years off and didn’t feel better but not worse like when I tried no caffeine.

So usually no on that as well but I do sometimes go a month or two without.