Tove Harris 2. AccountMar 1
Hilda Bastian

News-packed update on nextgen Covid vaccines this month at my @PLOS blog:

- Phase 2 results for a self-amplifying mRNA vaccine from Japan with a phase 3 trial recently closed off

- Preclinical results for an intranasal "universal" vaccine that provided some protection from coronaviruses, H1N1 flu, some bacterial infections, and an asthma allergen

- Opportunities to participate in intranasal vaccine trials in Finland and the US

And much more:
https://absolutelymaybe.plos.org/2026/03/01/progress-for-universal-vaccine-more-nextgen-covid-vax-news-update-no-38/

#Vaccines #Covid #Covid19

Progress for "Universal" Vaccine & More NextGen Covid Vax News (Update No 38) - Absolutely Maybe

This month, there are phase 2 results for a self-amplifying mRNA vaccine from Japan—and that vaccine’s developers have recently completed a phase…

Absolutely Maybe
Mar 1 at 9:03amWeb
Show threadDucky 🇨🇦Mar 2

@hildabast The Stanford TLR4 agonists/ovalbumin looks incredibly interesting and exciting for limited short-term use, but I worry that causing low-level inflammation long-term would increase the risk of heart disease, diabetes, and cancer. 😠

The Colombia paper on *their* universal vaccine (https://www.science.org/doi/10.1126/scitranslmed.adx5758 ) said that some people who never get sick are missing the ISG15 gene, which gives them low-level inflammation.

I know someone who never got sick, and they had *four* totally different cancers before they died. I wonder if they were missing ISG15.

Show threadHilda BastianMar 2
@ducky Not my area of expertise, but firstly I don't believe a vaccine could prevent all respiratory diseases, and secondly, there are other kinds of common non-respiratory infectious diseases etc.
Show threadDucky 🇨🇦Mar 2
@hildabast I encourage you to read the Columbia paper (or at least this lay article: https://scitechdaily.com/the-rare-mutation-that-makes-people-immune-to-viruses/ ). It's really exciting stuff.
The Rare Mutation That Makes People Immune to Viruses

A rare genetic condition that once looked like a weakness has revealed a hidden strength: immunity against nearly all viruses.

SciTechDaily