Gregory MSOxyxymatrine is an alkaloid with the property of immunomodulation. It inhibits experimental autoimmune encephalomyelitis (EAE) by promoting the production of interferon-β (IFN-β). It also reduces microglia/macrophage infiltration and polarization, lowered pro-inflammatory cytokine levels, and enhanced expression of IL-10 and IL-27. It upregulated the STING/TBK1/IR