trans women have said progesterone improves transition results for a long time, but doctors have been very hard to convince to prescribe because “no evidence” and “it might be harmful“.

Study has been done. Turns out it helps and isn’t harmful https://amsterdamumc.org/en/spotlight/addition-of-progesterone-leads-to-increased-breast-growth-for-transgender-women.htm

I’ll have to do a full blog post when the study is published.

Addition of Progesterone Leads to Increased Breast Growth for Transgender Women | Amsterdam UMC

The addition of the hormone progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender people following feminising hormone therapy. This is demonstrated by an Amsterdam UMC-led trial among 90 participants and these results are presented today at the European Professional Association for Transgender Health (EPATH) annual congress in Hamburg.

@sitharus I've had to give it to my wife for a very different (IVF) reason!

Was excited to discover this time, as opposed to two years ago, the injections are now available subcutaneous instead of just the muscular one in oil (that the first time we used I had to pay to be compounded :s )

@lachlan very few doctors in NZ will prescribe any sort of injections for transgender HRT, unfortunately

@sitharus Apparently, it can be used by men for birth control. If only you could find a doctor to give it to you for a 'different reason' (but, you know, not).

(Kinda like how 'I' had 'sleeping issues' at various chemists for Restavit that my wife just happened to get to before me that _completely accidentally_ helped with her morning sickness)

@sitharus fuckers there kept refusing my request for prog based on international studies since I started transition

we bet we will hardly get a sorry

@helle it’s the same over here, refused based on studies completely unrelated to GAHT using synthetic progestins. But they’ll still prescribe the much more harmful progestin cyproterone acetate!
@sitharus made my boobs bigger. source: girlfriend
@sitharus didn't you hear being trans is harmful or something? maybe you should just not be trans then everyone will be happy lolol

@sitharus This study has been making the rounds on fedi lately. It is extremely important to understand that there is a lot more context to it than its headline. The sample size was small, it isn't representative and there are reports of study participants not taking the medicine as prescribed.

https://hachyderm.io/@Impossible_PhD/115163805041049645

Doc Impossible (@[email protected])

Attached: 1 image @[email protected] @[email protected] Just want to note that there are some ENORMOUSLY IMPORTANT asterisks to the top-line that this article is blowing past. This is a PROSPECTIVE study. Absolutely nothing definitive. They're trying to set the stage for later, larger research. First: This is a 90-participant complex RCT. That means that there are THREE test and THREE control groups, meaning there's only 15 participants in each test and each control group. Samples this small are EXTREMELY vulnerable to false positives a day false negatives. Studies like these are good at finding combinations of doses that are particularly promising for later, larger research. That's what this study is really doing--an n of 15 is much too small to show a thing reliably. As a dead minimum, you need 30 participants. 100 is far better. Second: Both estrogen and progesterone were tested variables in this study, and the study found that higher estrogen levels than the Endocrine Society guidelines recommend helps breast development. If confirmed, that's a first in field finding, and a way bigger deal than the current headline. Third: the good news: This study uses detailed 3D modeling to track breast development, which is pretty clever, and a far better method than has been previously used to measure breast development. It should be a far more sensitive way to measure small changes over time. Fourth, and the big one: It sounds like one of the study participants is aware that several participants took their progesterone by boofing, rather than taking it orally as the study called for. This is a HUGE issue, esp. if boofing is as good a deal as people think. https://reddit.com/comments/1n9w2xz/comment/ncquqby

Hachyderm.io
@nina yes I’m aware of the limitations (I wrote about them a bit in my later blog post), however this is the first research done on this subject so I’ll take what I can get
@sitharus I feel like I need to prepare an essay for my upcoming follow-up now ​