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Kocharian, A., Redish, A.D. & Rothwell, P.E. Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind. Nature Neuroscience (2025).
https://www.nature.com/articles/s41593-025-02015-z
One of many exciting results: When mice change their mind about a choice (quitting out of the wait zone on our #RestaurantRow task), there is a dip in dopamine, even though there is no new information provided. Creating such a dip with optogenetic inhibition increases the likelihood of quitting.
Also available as a preprint on biorxiv. https://www.biorxiv.org/content/10.1101/2024.09.16.613237v1
Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind - Nature Neuroscience
Differences in neuroeconomic decision-making influence nucleus accumbens dopamine dynamics and reflect choice confidence during evaluation, as well as past and future value during re-evaluation, which can causally lead to change-of-mind behaviors.
El Duvelle Neuro