#Replication #Restriction of #Influenza #H5N1 Clade 2.3.4.4b Viruses by #Human Immune Factor, 2023–24, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/31/1/24-1236_article

We show that human myxovirus resistance protein 1 (MxA) suppresses replication of influenza H5N1 viruses isolated from #mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral #polymerase complex components from a human-adapted MxA-resistant strain in vitro.