
I'm seconding Ghalgren, or anything my Samuel Delany
@farah
"Do Androids Dream of Electric Sheep?" Philip K Dick
And
"Down and Out in the Magic Kingdom" Cory Doctorow
Come to mind
@farah Kim Stanley Robinson - Aurora
Like many other replies, I found it in a bookshop after rejecting several parts of series
Some of these are new, but don't appear to have sequels imminent:
Gods, Monsters, and the Lucky Peach, by Kelly Robson
The Vanished Birds by Simon Jimenez
The Jinn-Bot of Shantiport by Samit Basu
The Terraformers by Annalee Newitz
Nalo Hopkinson, Karen Lord, and John M. Ford all have a number of stand-alone SF novels
The Lathe of Heaven by UK LeGuin, also Always Coming Home is technically SF
Sci-fi books
@farah To Be Taught, If Fortunate - Becky Chambers
(it’s a short novella, set many light years from earth which means that any news is years/ decades out of date)
"Embassytown" by China Miéville
I also thought "Passage at Arms" by Glen Cook was standalone, but checking I see it's technically part of the 'Starfishers' universe. Still, it works perfectly well as a standalone.
For books that were written as standalones but gained sequels after the fact, 'Neuromancer' by William Gibson and 'The Pride of Chanur' by C. J. Cherry comes to mind.
The Knife and the Serpent, Tim Pratt. Multiverse done properly.
Unwillingly to Earth, Pauline Ashwell. Episodes in social engineering.
Mastodonia, Clifford Simak. Time travel done kindly.