‘I’d like to read a sci-fi book that’s not part of a series’ challenge
Some of these are new, but don't appear to have sequels imminent:
Gods, Monsters, and the Lucky Peach, by Kelly Robson
The Vanished Birds by Simon Jimenez
The Jinn-Bot of Shantiport by Samit Basu
The Terraformers by Annalee Newitz
Nalo Hopkinson, Karen Lord, and John M. Ford all have a number of stand-alone SF novels
The Lathe of Heaven by UK LeGuin, also Always Coming Home is technically SF