Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation

Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific. This study takes advantage of the young sex chromosomes of Drosophila miranda to explore how former autosomes acquire sex chromosome-specific regulatory programs, revealing the consequences that these mechanisms have for the evolution of sex chromosome architecture.