Disk space can be a problem if you're only installing one or two #Flatpak applications (which, by chance, will use two different runtimes). If, like me, you have more than sixty applications sharing a small number of runtimes, it's less of an issue.
I also think that distributions designed from the outset to make massive use of Flatpak (like #Fedora Atomic Desktop) will be even less problematic in the future.
