Ron Beavis ❌A GPMDB ubiquitination PTM diagram for human tumour protein p63 (#TP63:p). The 'zines are pretty adamant that the protein is a Ub substrate of the anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003458/). It has not been observed to be afflicted with SUMOylation. #proteomics #anapc
STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis
The N-terminally truncated isoform of p63 (ΔNp63) is overexpressed in some forms of squamous cell carcinoma (SCC). Here we show that the anaphase-promoting complex/cyclosome (APC/C) degradation machinery plays an essential role in regulating the ...