Ron Beavis ❌A GPMDB ubiquitination PTM diagram for human aurora kinase A (#AURKA:p). Involved in centrosome maturation & mitosis in general, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175). #proteomics #anapc
Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the unidirectional cell cycle phases. Several different mechanisms ...