@davidho You don't want to wait to learn more about the work of the nobel prize winners? Watch this brandnew documentary
https://www.arte.tv/en/videos/109391-000-A/the-mrna-revolution/
Covid-19 first brought it to public attention, but messenger RNA was discovered sixty years earlier. Through the many trials and pitfalls of its pioneering researchers and developers, this documentary tells the fascinating story of a medical revolution.
@davidho what happened at Penn is chronic in academia as is funder bias. Regarding this manuscript being rejected by Nature & Science and accepted by Immunology, it’s a reasonable outcome. Modified NA bases by 2005 weren’t novel and their impact on inflammation response to mRNA is more specialized than general interest. Hindsight is 20/20 after all.
External leadership is needed to realize genuine systemic reform. But, if SOS behavior in mCDR is any indication, it’s not happening anytime soon.