New paper from the lab!

We observed beautiful sequences of spiking activity during sleep in the « head-direction cortex » (aka post-subiculum), traveling along its dorsoventral axis. Using in vivo data analysis, computation models, and slice physiology, we show that the hyperpolarization-activated current (Ih) supports this sequential neuronal activation. Analyzing data from other cortical regions, we believe that this is a general mechanism of spiking sequences during sleep.

See our preprint:
https://www.biorxiv.org/content/10.1101/2023.09.12.557442v1

This manuscript contains obviously more than the short summary above. Comments are more than welcome!

Huge kudos to @dlevenstein and @dhruvmehrotra5 for their hard work, Adrian Duszkiewicz, Brendon Watson, and Sofia Skromne Carrasco for the data. Also, great collaboration on the slice physiology with Sam Booker and Angelika Kwiatkowska at the University or Edinburgh. Big thanks to all the funding agencies (I mean, the tax payers) and other organizations for the financial support!