Kid is asleep so it's back to the lab for me.
After a bit of cable management we've got the first signs of life out of the board.
Applied 12V power to the input and it's drawing 3.6 mA. This is normal and expected, as all power rails are supposed to be off at this point other than the raw input and the 3.3V standby rail driven by an LDO to power the supervisor.
Next step is to put some code on the supervisor and start bringing up more power rails.