Mark KaplanJan 28, 2023
marionpepper
So this is when I am going to miss the bird site and the ability to widely broadcast some cool findings very easily. We have three new Pepper lab manuscripts to discuss. The first to make it online is beautiful work from my graduate student Laila Shehata identifying a critical role for IL4 in memory B cell selection in the GC:
https://www.biorxiv.org/content/10.1101/2023.01.26.525749v1
Jan 27, 2023 at 4:12pmWeb
Show threadEnrique BarcelliJan 27, 2023

@marionpepper why would you miss the bird site?

Unless you love engaging with bots... here you can converse with us Humans 😉

However, sorry I am not qualified to peer-review the paper 😬

Trust you'll find some qualified folks here though.

(Jokes aside, I understand what you mean, and I am glad you are sharing this here as I believe the scientific community will little by little flock to the Fediverse) 😊

Show threadmarionpepperJan 27, 2023
@kikobar I definitely don’t miss the bots. 🤓And I am not missing it enough to go back BUT that being said, I think it’s ok to admit that it is easier to find people and have them find us and our work on the bird site.
Show threadBen MeekinsJan 27, 2023
@marionpepper Dr. Pepper, I run a weekly (Fridays, 10:30 PM EST typically) science-focused livestream. Would you be interested in presenting some of your group's work? Talks are seminar-style but less formal, and there's no hard time limit on either the talk or the Q&A afterward to facilitate getting into all the cool details. If this is of interest, please reply, DM, or email (meekins AT sc DOT edu) me. --Ben
Show threadCarolyn KingJan 28, 2023
@marionpepper cool paper Marion! just sorting through it now. we are really curious about the T cell contribution to this process - re double versus single producers of IL4/21. we had reanalyzed some of the sequencing data from the Craft paper and saw that dual producers are enriched for Hif targeted genes...
Show threadCarolyn KingJan 28, 2023
@marionpepper so based on earlier data showing reciprocal regulation of Bcl6/Hif wonder if different subsets of Tfh cells (reaching a different equilibrium of these TFs) could contribute to the B selection processes you are describing here ... could also relate to some of the GC shutdown events described by @victora_lab (those late phase mTfh cells with high Hif/lower Bcl6 look at lot like Tregs except they don't express Foxp3 😅)
Show threadmarionpepperJan 28, 2023
@ImmunologyKing @victora_lab thanks, Carolyn! Yep, agree- what a given activated GC Tfh is producing is key to this process and creates the potential for diverse outcomes.