marionpepperJan 27, 2023
So this is when I am going to miss the bird site and the ability to widely broadcast some cool findings very easily. We have three new Pepper lab manuscripts to discuss. The first to make it online is beautiful work from my graduate student Laila Shehata identifying a critical role for IL4 in memory B cell selection in the GC:
https://www.biorxiv.org/content/10.1101/2023.01.26.525749v1
Show threadCarolyn King
@marionpepper cool paper Marion! just sorting through it now. we are really curious about the T cell contribution to this process - re double versus single producers of IL4/21. we had reanalyzed some of the sequencing data from the Craft paper and saw that dual producers are enriched for Hif targeted genes...
Jan 28, 2023 at 8:54amWeb
Show threadCarolyn KingJan 28, 2023
@marionpepper so based on earlier data showing reciprocal regulation of Bcl6/Hif wonder if different subsets of Tfh cells (reaching a different equilibrium of these TFs) could contribute to the B selection processes you are describing here ... could also relate to some of the GC shutdown events described by @victora_lab (those late phase mTfh cells with high Hif/lower Bcl6 look at lot like Tregs except they don't express Foxp3 😅)
Show threadmarionpepperJan 28, 2023
@ImmunologyKing @victora_lab thanks, Carolyn! Yep, agree- what a given activated GC Tfh is producing is key to this process and creates the potential for diverse outcomes.