Manlio De DomenicoObesity (as measured by BMI) is linked to many health problems that can be fatal. Using a genetic risk score including 2,446 variants, obesity was found to increase the risk of 316 different diseases, being connected to a variety of health problems in the circulatory, genitourinary, respiratory, musculoskeletal, and dermatologic systems.
Genomics and phenomics of body mass index reveals a complex disease network - Nature Communications
Elevated body mass index is heritable and associated with many health conditions that impact morbidity and mortality. Here, the authors identify greater than 900 genetic loci for body mass index (BMI) and find over 300 diagnoses associated with increasing BMI.