SarahMCookeDec 2, 2022
Wes Ely MD 

#Blood #Clots in COVID:🩸

Blood thinner Apixaban given as prevention (not treatment) vs placebo to >400 #COVID pts leaving hospital did not ⬇️ rehospitalization.

Awaiting full trial results
bit.ly/3uhlHQC

This HEAL study
📍Micro-clots remain a leading theory as to why millions suffer #LongCovid
📍These excellent investigators were not testing that theory but rather the idea that preventing overt clotting might help
📍This study did not aim to test neuro cognitive benefits of anticoagulants.

Dec 1, 2022 at 3:20pmWeb
Show threadCharles T. LowDec 1, 2022
@WesElyMD Thank you for including a mention of the limitations. This can confuse non-scientists, but is how real (valid) science works!
Show threadJ.H.NoyesDec 2, 2022
@WesElyMD
N-protein exploits Lectin Pathway component MASP-2 to dysregulate the foundation of the immune response. Putting a new roof on a house with a crack in the foundation won't solve the problem for very long, if at all.
@Mathlover
Show threadHarriet CarrollJul 2, 2023
@WesElyMD considering microclots and clotting in general is accompanied by platelet activation, itd be nice to see antiplatelet(s) + dabigatran (potentially better fibrinolytic properties vs DOAC)