Stepping Into the Unknome

A database of neglected genes may help unlock the mysteries hiding in the overlooked regions of the proteome.

The known unknowns of biology: welcome to the unknome

We know almost nothing about thousands of proteins in the human body

Scientists have created an "unknome" of proteins encoded by human genes, whose existence is known but whose functions are mostly not

We know almost nothing about thousands of proteins in the human body

Scientists have created an "unknome" of proteins encoded by human genes, whose existence is known but whose functions are mostly not

The 'unknome': A database of human genes we know almost nothing about

Researchers from the United Kingdom hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not.

The ‘unknome’ catalogs nearly 2 million proteins. Many are mysterious

Scientists have unveiled a new database that emphasizes how much we still don’t know about human proteins and genes.

Functional unknomics: Systematic screening of conserved genes of unknown function

The human genome contains many genes whose function remains mysterious, despite decades of research; this study presents a publicly available “Unknome database” and reveals that genetic screens that focus on this "unknome" can help shed light on fundamental biological processes.

The Unknome: Researchers Just Created a Database of Our Most Mysterious Genes

To increase our understanding of our genetic blueprints researchers have put together a database of genes we know almost nothing about.