Evidence for ~12-h ultradian gene programs in humans
https://www.nature.com/articles/s44323-024-00005-1
https://news.ycombinator.com/item?id=41208934
* prospective, temporal transcriptome profiling of peripheral white blood cells f. 3 healthy humans
* ~12-h transcriptional rhythms in RNA, protein metabolism
* strong homology to circatidal gene programs prev. identified in Cnidarian marine species
Ultradian rhythms: https://en.wikipedia.org/wiki/Ultradian_rhythm
Chronobiology: https://en.wikipedia.org/wiki/Chronobiology
#ultradian #circadian #chronobiology #biology #BiologicalRhythms
Evidence for ~12-h ultradian gene programs in humans - npj Biological Timing and Sleep
Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.
#Ultradian rhythms and
#schizophrenia: @MadelineRScott &co identify 12-hour rhythms in gene expression in the human
#DLPFC, showing that the rhythms of some of these genes are lost/shifted in people with schizophrenia @McClungColleen @LabZhu
#PLOSBiology https://plos.io/3DbLChq 
Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.
#Ultradian rhythms and
#schizophrenia: @MadelineRScott &co identify 12-hour rhythms in gene expression in the human
#DLPFC, showing that the rhythms of some of these genes are lost/shifted in people with schizophrenia @McClungColleen @LabZhu
#PLOSBiology https://plos.io/3DbLChq 
Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.
#Ultradian rhythms and
#schizophrenia: @MadelineRScott &co identify 12-hour rhythms in gene expression in the human
#DLPFC, showing that the rhythms of some of these genes are lost/shifted in people with schizophrenia @McClungColleen @LabZhu
#PLOSBiology https://plos.io/3DbLChq 
Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.
Victoria Stuart 🇨🇦 🏳️⚧️
PLOS Biology