Benjamin Carr, Ph.D. 👨🏻‍💻🧬May 16, 2025
A dangerous #Ecoli strain has emerged; a small #mutation may explain its rise
A sweeping genetic analysis by researchers at #CDC suggests a tiny mutation in one of the #bacteria's molecular weapons may be behind the strain's rise. The mutation the CDC researchers found was in one of these #T3SS effectors, a protein called #EspW. The CDC researchers suggest this could help E. coli when it's on #lettuce and other #produce.
https://arstechnica.com/health/2025/05/a-dangerous-e-coli-strain-has-emerged-a-small-mutation-may-explain-its-rise/
A dangerous E. coli strain has emerged; a small mutation may explain its rise

It’s unclear what the mutation does, but it might make E. coli stealthy on lettuce.

Ars Technica
CellBioNewsMar 4, 2025

Widespread #plant #metabolite shows potential for combating #bacterial #diseases in #crops.

#agriculture #food_security #erucamide #TypeIII_Secretion #T3SS #injectisome

https://phys.org/news/2025-03-widespread-metabolite-potential-combating-bacterial.html

Widespread plant metabolite shows potential for combating bacterial diseases in crops

Bacterial pathogens, such as those causing rice bacterial blight, tomato bacterial wilt, and kiwifruit bacterial canker, pose significant threats to global agriculture. However, effective pesticides to control these diseases are scarce, with copper-based bactericides and antibiotics offering limited efficacy and posing environmental risks.

Phys.org
PLOS BiologyMay 1, 2024
This study uses a #FluidFM-based injection approach to show that establishment of a #Salmonella replicative niche in the cytosol of enteroid cells (when uncoupled from invasion) does not require #flagellin or #T3SS effectors #PLOSBiology @Microbio_ETH https://plos.io/3UBBUhz
Direct Salmonella injection into enteroid cells allows the study of host–pathogen interactions in the cytosol with high spatiotemporal resolution

A previous study in PLOS Biology developed a FluidFM-based approach to inject organelles into living cells. Using this technology, this study shows that establishment of a Salmonella Typhimurium replicative niche in the cytosol of enteroid cells, when uncoupled from invasion, does not require flagellin or type III secretion system effectors.

Sarah MelamedDec 6, 2022

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
https://www.sciencedirect.com/science/article/pii/S1097276522002192

#pathogen #caspase #signaling #bacteria #t3ss