PLOS BiologySep 12, 2025
We know that the mTORC2 complex regulates lipid synthesis in #cancer, but how? This study shows that RICTOR (reg subunit of mTORC2) regulates synthesis of #sphingolipids & #gangliosides by modulating expression of the UGCG enzyme, so promoting #BreastCancer growth @PLOSBiology https://plos.io/42q1Hg4
Justin CarrardAug 12, 2025

#sphingolipids are increasingly recognised as #biomarkers of #cardiometabolic #health.

The SphingoHIIT, a RCT, showed that a single #hiit session does not alter blood sphingolipid levels in healthy young adults, under tightly controlled conditions (diet, menstrual timing, multi‑timepoint sampling).

This is an interesting feature for potential biomarkers of cardiometabolic risk.

Congrats to Dr Thomas Angst on his successful doctoral thesis completion!

https://www.csbj.org/article/S2001-0370(25)00268-5/fulltext

TheLipidHoffAug 27, 2023
8th #lipidomics Forum and 2nd International Lipidomics Society Meeting kicking off in Vienna, Austria with a keynote by Professor Frances Platt, PhD on #sphingolipids in lysosomal storage diseases https://ilsconf.org/program
Program – ILS Annual Conference