Richard Michael Blaberhttps://theconversation.com/hay-fever-antihistamines-and-the-evidence-on-dementia-risk-283306. "More recent #evidence is reassuring. A #nationwide #study found no evidence that prolonged use of second-generation #antihistamines increased #dementia #risk. The #research does not suggest that occasional use of a newer, less #sedating #antihistamine causes dementia." See: https://www.jaci-inpractice.org/article/S2213-2198(25)00954-7/abstract (abstract & refs. only).
Chuck Darwin#Alcohol has impressive #sedating effects and targets the GABA receptor in the brain, which increases the activity of #GABA — the brain’s major inhibitory neurotransmitter — and mediates the calming effect of alcohol. (Ambien, and benzodiazepines such as Klonopin and Ativan, also modulate the GABA receptor, but at a different site.)
The problem for sleep is that alcohol is rapidly absorbed and typically cleared within two to five hours, so the sedation vanishes, leaving you hyper alert in the middle of the night
https://www.washingtonpost.com/wellness/2023/01/12/how-alcohol-affects-depression-anxiety/
