As a medical school professor, I've watched spermidine and polyamine supplements explode in popularity as "anti-aging" compounds.

But new research from Tokyo University of Science reveals a disturbing double life.

In healthy cells, polyamines activate eIF5A1, powering mitochondria and cellular cleanup (autophagy) — the "anti-aging" effect.

But in cancer cells? The SAME molecules activate eIF5A2 ins... https://www.sciencedaily.com/releases/2026/03/260302030657.htm

#Polyamines #CancerResearch #Longevity #MetabolicHealth #Spermidine

The structure of Clostridium leptum carboxyspermidine decarboxylase was compared with those of homologs from other gut constituents to reveal active-site and domain variation within this enzyme family #Polyamines #Spermidine #GutMicrobiome https://t.co/LHNCd50dIE
Structure of Clostridium leptum carboxyspermidine decarboxylase and comparison to homologs prevalent within the human gut microbiome

A high-resolution structure of carboxyspermidine decarboxylase, a member of the PLP-dependent β/α-barrel-fold decarboxylase family, is analyzed.

Acta Crystallographica Section F
Our latest #JIPB Invited Expert Review explores #polyamines and the role that these valuable bio-stimulants and endogenous signaling molecules play in #PlantDevelopment and #stress response mechanisms.
https://doi.org/10.1111/jipb.13796
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