Toxoplasmosis: Researchers identify protein that evolved alongside infection machinery

Toxoplasmosis is an infectious disease found worldwide, caused by the single-celled parasite Toxoplasma gondii. In humans, infection poses a particular risk to pregnant women, as it can lead to birth defects. Like the closely related malaria pathogen—Plasmodium falciparum—and other related species, T. gondii possesses special organelles, so-called rhoptries and micronemes, for infecting the host cell.

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CLAMP complex helps parasites enter human cells

Apicomplexan parasites are a group of single-celled organisms responsible for several serious and prevalent diseases, from malaria, to a severe childhood diarrhea (cryptosporidiosis), to toxoplasmosis—a disease that endangers pregnant women and fetuses, and is the reason pregnant women are told to avoid changing cat litter.

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