Jim HammerandFeb 9, 2023
I recently spoke with Dr. Philip Adamson, chief medical officer of Abbott's heart failure business, to catch up on how #SARSCoV2 affects the cardiovascular system, #microclotting, long-term damage from #covid19 and how physicians are thinking differently about extracorporeal membrane oxygenation (#ECMO) to save patients' lives. https://www.medicaldesignandoutsourcing.com/abbott-heart-failure-covid-mechanisms-cardiovascular/
COVID-19's mechanisms are becoming clearer, Abbott's heart failure CMO says

In most diseases we've learned how to treat, we're able to do so "because we understand the fundamental mechanism," Dr. Philip Adamson said.

Medical Design and Outsourcing
Tatiana TrifanDec 8, 2022

#LongCovid #microclotting

"Some long COVID researchers have suspected smaller, less obvious blood clots may be causing many of the puzzling symptoms reported by patients [...].
The theory is that these weird and persistent clots, called microclots, might be blocking delicate blood vessels throughout the body, and stopping oxygen from getting to where it needs to go, causing everything from shortness of breath and organ damage to brain fog and debilitating fatigue."

https://www.webmd.com/lung/news/20221207/microclots-may-explain-long-covid-symptoms/

Tiny, Menacing Microclots May Explain Long COVID’s Symptoms

Early in the pandemic, doctors noticed the sickest patients had high numbers of blood clots, which caused problems and killed patients long after they left the hospital. Some long COVID researchers suspect something similar may cause puzzling symptoms of long COVID.

WebMD
Tatiana TrifanNov 25, 2022

#LongCovid #microclotting

"Our data propose a molecular mechanism for potential amyloidogenesis of SARS-CoV-2 S-protein in humans facilitated by endoproteolysis. The prospective of S-protein amyloidogenesis in COVID-19 disease associated pathogenesis can be important in understanding the disease and long COVID-19."

https://pubs.acs.org/doi/10.1021/jacs.2c03925#