Regenerative Research Fdn/NSCI🔊 Check out the latest preprint from David Butler & team: development of an #intrabody collection that targets a-Synuclein, a key protein that accumulates in Parkinson's disease. Efficacy data were generated using #organoids from PD patient stem cell lines in vitro as well as with two in vivo models.
#ParkinsonAwarenessMonth #NeuraCell
This work was supported by the Michael J. Fox Foundation, Parkinson's Foundation, NIH's NIDDK & NIA, & NYSDOH.
Preprint | https://zurl.co/M4aF
Engineered Nanobodies With Programmable Target Antigen Proteolysis (Ptap) Fusions Regulate Intracellular Alpha-synuclein in Vitro and in Vivo
Alpha-synuclein (αSyn) aggregation and the formation of Lewy pathology (LP) is a foundational pathophysiological phenomenon in synucleinopathies. Delivering therapeutic single-chain and single-domain antibodies that bind pathogenic targets can disrupt intracellular aggregation. The fusion of anti...
